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Not yet medically reviewed — information on this site is in preparation and has not been verified by a medical reviewer.
Drug index / Stimulant / Cathinone
Stimulant

Cathinone

Cathinone is a stimulant compound — the natural active ingredient in the khat plant, and the chemical parent of the synthetic 'bath salts' family (mephedrone, MDPV, methylone, alpha-PVP/'flakka' and others). Structurally related to amphetamine, cathinones range from the mild natural compound to potent, dangerous synthetics linked to psychosis and death. Natural cathinone is Schedule I in the US; most synthetic cathinones are Schedule I or prosecutable as analogues.

Overview

Cathinone is a naturally occurring stimulant found in the leaves of the khat plant (Catha edulis), and it is the structural template for a large family of synthetic derivatives known as substituted or synthetic cathinones — the drugs widely sold as 'bath salts'. The natural compound produces a mild, khat-chewing stimulation; the synthetic derivatives, engineered to mimic and often exceed cocaine, methamphetamine, and MDMA, are far more potent and dangerous. This page covers the cathinone class as a whole; for the natural plant see the khat page, and for specific synthetic members see the mephedrone, MDPV, methylone, and 3-MMC pages.

Source: DEA; NIDA; peer-reviewed literature (NIH/PMC)

Chemistry & mechanism of action

Cathinones are structurally related to amphetamine and act as central nervous system stimulants: they increase the activity of dopamine, norepinephrine, and serotonin by promoting their release and blocking their reuptake, raising levels of these neurotransmitters in the brain. This produces stimulation, euphoria, and alertness. Synthetic cathinones vary widely in potency and which transporters they target — some (like MDPV) are extremely potent dopamine-norepinephrine reuptake inhibitors, which contributes to their intense, compulsive, and dangerous effects compared with the mild natural compound.

Source: NIDA; peer-reviewed literature (NIH/PMC)

Effects

Effects are stimulant-like: euphoria, increased energy, alertness, sociability, and raised heart rate and blood pressure. The natural cathinone in khat is comparatively mild; synthetic cathinones can produce powerful stimulation resembling cocaine, methamphetamine, or MDMA, often with a strong compulsion to redose. Higher doses and more potent synthetics bring agitation, paranoia, hallucinations, and — notably — a documented pattern of severe, sometimes violent, psychotic episodes ('excited delirium'). A comedown with fatigue, low mood, and craving is common.

Source: NIDA; peer-reviewed literature (NIH/PMC)

Risks & harms

The natural cathinone in khat is a relatively mild stimulant, but synthetic cathinones ('bath salts') are among the more dangerous stimulants in circulation. They strain the cardiovascular system — dangerously high heart rate, blood pressure, chest pain, and risk of heart attack and stroke — and can cause severe hyperthermia (overheating), seizures, kidney failure, and rhabdomyolysis (muscle breakdown). Psychiatrically they are notorious for agitation, paranoia, hallucinations, and violent, self-endangering 'excited delirium', which has been linked to deaths. Because formulas change constantly to evade the law, potency and identity are wildly unpredictable, dosing is guesswork, and products sold as one cathinone are frequently another or a mixture; contamination, including with fentanyl in the broader illicit supply, is a risk. Dependence and compulsive redosing develop readily. Injecting or sharing equipment adds infection risk. Anyone showing dangerously high temperature, chest pain, seizures, extreme agitation or psychosis, or collapse needs emergency care — call 911, and Poison Control at 1-800-222-1222 can advise. This page has not yet been medically reviewed.

Source: NIDA; DEA; SAMHSA; peer-reviewed literature (NIH/PMC)

Images

Visual references coming soon.

If it’s too intense

If an experience becomes overwhelming, the goal is to stay safe and let it pass — most difficult experiences ease as the drug wears off.

  • Get to a calm, safe space with someone you trust who is sober and can stay with you.
  • Cool down if you’re overheating — move somewhere cool, remove extra layers, rest. Overheating is especially a risk with stimulants and MDMA.
  • Sip water to thirst — but don’t over-hydrate. Drinking large amounts of plain water (especially after MDMA) can dangerously dilute your blood sodium (hyponatremia). Electrolytes help more than volume.
  • Slow your breathing — long, slow exhales help settle a racing heart and anxiety.
  • A sugary drink, fruit juice, or a snack can ease shakiness and the anxiety that comes with low blood sugar.
  • Do not take more, and do not add another substance to manage it. Redosing or adding something else (including a sedative like a benzodiazepine) can make things worse, not better.

With stimulants, overheating and a racing heart are the main concerns — get somewhere cool, stop any physical activity, and don't take more.

Call 911 (or Poison Control, 1-800-222-1222) right away for chest pain, a very high body temperature, a seizure, unconsciousness, or severe confusion. These are medical emergencies, not something to wait out.

Source: general harm-reduction guidance from SAMHSA, NIH/NIDA, and MedlinePlus, in our own words. Draft — not yet medically reviewed.

Forensic dossier

Draft · every field is source-cited or marked “Unknown — pending review”

Identity

IUPAC name
(2S)-2-amino-1-phenylpropan-1-onePubChem PUG-REST · retrieved 2026-06-18
SMILES
C[C@@H](C(=O)C1=CC=CC=C1)NPubChem PUG-REST · retrieved 2026-06-18
InChIKey
PUAQLLVFLMYYJJ-ZETCQYMHSA-NPubChem PUG-REST · retrieved 2026-06-18
Synonyms / aliases
khat, qat, Cathinone, Norephedrone, d-Cathinone, Catinona, Cathinonum, alpha-Aminopropiophenone, S-(-)-cathinone, (-)-alpha-Aminopropiophenone, Cathinine, 1-propanone, 2-amino-1-phenylPubChem PUG-REST + seed aliases · retrieved 2026-06-18

Composition

Composition
N/A — single compound (see Identity)

Physical / pill characteristics

Dosage form
Unknown — pending review (no Rx/OTC label; illicit — pill visuals = FIRST-PARTY submissions only, never generated or scraped)
Route
Unknown — pending review
Shape
Unknown — pending review
Color
Unknown — pending review
Imprint
Unknown — pending review
Score
Unknown — pending review

Scheduling & legal status

US schedule
Unknown — pending review
International
Unknown — pending review

Effects, risks & interactions

Effects
Cathinone is the natural stimulant alkaloid found in the leaves of the khat plant — the parent compound from which the synthetic cathinones ("bath salts") are chemically derived. Chewed fresh as khat, a practice traditional for centuries in parts of East Africa and the Arabian Peninsula, it produces a mild, amphetamine-like stimulation: alertness, talkativeness, mild euphoria and appetite suppression. The compound is chemically unstable and breaks down as the leaf dries, which is why khat is chewed fresh.PubChem CID 62258 + NIDA Synthetic Cathinones (khat context) · retrieved 2026-06-18
Risks
Cathinone's effects and risks are milder than those of the potent synthetics built from it, but its sympathomimetic action still raises heart rate and blood pressure, and heavy, sustained khat use is linked to cardiovascular strain, dental and oral problems, disturbed sleep and mood, and dependence. As a natural product chewed as plant material of relatively consistent, modest potency, it does not carry the unknown-dose danger of the synthetic powders in the same way — but the synthetic cathinones derived from it (mephedrone, MDPV and others) are far more potent and dangerous, which is precisely why cathinone matters as their chemical starting point.PubChem CID 62258 + NIDA Synthetic Cathinones (khat context) · retrieved 2026-06-18
Interactions
Unknown — pending review

Dosage

Pending medical reviewer

Sources

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