Independent · evidence-based · non-judgmentalDraft · interaction guidance
Not yet medically reviewed — information on this site is in preparation and has not been verified by a medical reviewer.
Harm reduction

Drug interactions

Combining drugs changes the risk. This tool gives pair-specific ratings where clinical literature supports them (for example cocaine + ketamine), and category-levelguidance otherwise — each drawn from primary clinical sources. Combinations we can’t rate from those sources stay marked Unknown — pending review, which is not a claim of safety.

Check two drugs

Pick two substances to see interaction guidance — pair-specific where the evidence exists, category-level otherwise.

By category

Tap a cell for detail. Empty/grey cells are Unknown — pending review, not a safety claim.

PsycEmpaDissStimDeprOpioCannInhaPres
Psychedelic
Empathogen
Dissociative
Stimulant
Depressant
Opioid
Cannabinoid
Inhalant
Prescription
DangerousUnsafeCautionUnknown