Not yet medically reviewed, information on this site is in preparation and has not been verified by a medical reviewer.
Drug index / Depressant / Nimetazepam
Depressant

Nimetazepam

Nimetazepam, sold historically as Erimin and known on the street as Erimin-5 or Happy-5, is a controlled benzodiazepine. A Class C controlled drug and Fourth Schedule specified drug in Singapore, with no named section 17 trafficking threshold.

Overview

Nimetazepam is a benzodiazepine developed as a sedative-hypnotic medicine and marketed in parts of Asia under the Erimin name, including as Erimin 5. It is CAS 2011-67-8, PubChem CID 4496, molecular formula C₁₆H₁₃N₃O₃, and chemically a nitrobenzodiazepinone — IUPAC 1-methyl-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one.

The original proprietary product is no longer a normal current medicine: UNODC reports that licit manufacture of Erimin&nbsp;5 was discontinued in 2015. The name persists in illicit markets, where tablets are sold as <strong>Erimin-5</strong> or <strong>Happy-5</strong> — both names Singapore's Central Narcotics Bureau lists. That gap between a discontinued pharmaceutical and a continuing street name is exactly why this page exists: a reader who meets &ldquo;Erimin&rdquo;, &ldquo;Erimin-5&rdquo; or &ldquo;Happy-5&rdquo; in a judgment needs to be able to resolve it to nimetazepam.

It is controlled in Schedule&nbsp;IV of the United Nations Convention on Psychotropic Substances of 1971. The INCB Green List entry reads: &ldquo;NIMETAZEPAM — 1,3-dihydro-1-methyl-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one&rdquo;.

Source: PubChem CID 4496; INCB Green List, 36th edition; UNODC, Synthetic Drugs in East and Southeast Asia 2026; Singapore Central Narcotics Bureau.

Chemistry & mechanism of action

Nimetazepam belongs to the benzodiazepine class. Benzodiazepines enhance inhibitory signalling at GABA-A receptors, reducing central nervous system activity and producing sedation, impaired alertness and other depressant effects. Experimental receptor work identified nimetazepam as a high-affinity benzodiazepine-receptor ligand.

Human metabolism studies identify nitrazepam and 7-aminonimetazepam among its metabolites, so a urine screen may detect nitrazepam in someone who took nimetazepam. The two are closely related but distinct compounds and should not be treated as the same drug.

These are class and laboratory findings describing pharmacology. They do not make nimetazepam an approved medicine.

Source: PubChem CID 4496; PubMed 2857046 (benzodiazepine-receptor binding); PubMed 23085494 (metabolism).

Effects

Expected benzodiazepine effects include drowsiness, slowed reactions, impaired judgement, reduced coordination, and memory or concentration problems.

Impairment outlasts the subjective sense of being affected, which is what makes driving and similar tasks dangerous well after someone feels recovered.

Illicit tablets add a separate uncertainty that no description of effects can cover: the name or appearance of a tablet does not establish its actual contents or its strength.

Source: FDA benzodiazepine class boxed-warning update; Singapore Central Narcotics Bureau.

Risks & harms

Risks rise sharply when a benzodiazepine is combined with opioids, alcohol or other central nervous system depressants: profound sedation, respiratory depression, coma and death can occur. This is the substance of the FDA's boxed warning for the whole benzodiazepine class.

Repeated use can lead to physical dependence. Abrupt dose reduction or stopping after dependence has developed can cause serious withdrawal, including seizures. A taper needs a prescriber.

Because genuine Erimin&nbsp;5 has not been manufactured since 2015, a tablet sold under that name has an unverified identity and an unverified dose. Neither can be established without laboratory analysis.

Source: FDA benzodiazepine class boxed-warning update; UNODC, Synthetic Drugs in East and Southeast Asia 2026.

Images

Visual references coming soon.

If it’s too intense

If an experience becomes overwhelming, the goal is to stay safe and let it pass, most difficult experiences ease as the drug wears off.

  • Get to a calm, safe space with someone you trust who is sober and can stay with you.
  • Cool down if you’re overheating, move somewhere cool, remove extra layers, rest. Overheating is especially a risk with stimulants and MDMA.
  • Sip water to thirst, but don’t over-hydrate. Drinking large amounts of plain water (especially after MDMA) can dangerously dilute your blood sodium (hyponatremia). Electrolytes help more than volume.
  • Slow your breathing, long, slow exhales help settle a racing heart and anxiety.
  • A sugary drink, fruit juice, or a snack can ease shakiness and the anxiety that comes with low blood sugar.
  • Do not take more, and do not add another substance to manage it. Redosing or adding something else (including a sedative like a benzodiazepine) can make things worse, not better.

With depressants, the danger is over-sedation: if someone is very drowsy, hard to wake, or breathing slowly, treat it as an emergency.

Call 911 (or Poison Control, 1-800-222-1222) right away for chest pain, a very high body temperature, a seizure, unconsciousness, or severe confusion. These are medical emergencies, not something to wait out.

Source: general harm-reduction guidance from SAMHSA, NIH/NIDA, and MedlinePlus, in our own words. Draft, not yet medically reviewed.

Dosage

Pending medical reviewer

Sources

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