Independent · evidence-based · non-judgmentalDraft · pending medical review
Not yet medically reviewed — information on this site is in preparation and has not been verified by a medical reviewer.
Drug index / Empathogen / MDMA
Empathogen

MDMA

1-(1,3-benzodioxol-5-yl)-N-methylpropan-2-amine

Detailed, medically-reviewed information for MDMA is being prepared.

Overview

MDMA (3,4-methylenedioxymethamphetamine), commonly called ecstasy or molly, is a synthetic drug that acts as both a stimulant and a mild hallucinogen, producing feelings of increased energy and emotional warmth. Material sold as "molly" is frequently not pure MDMA and may contain other substances.

Source: U.S. National Institute on Drug Abuse (NIDA), nida.nih.gov — MDMA (Ecstasy/Molly); PubChem, U.S. National Library of Medicine CID 1615.

Chemistry & mechanism of action

MDMA increases the activity of three brain chemicals — serotonin, dopamine, and norepinephrine. The large release of serotonin is thought to underlie the elevated mood and emotional closeness people report, and also contributes to the after-effects as serotonin is depleted. Its molecular formula is C11H15NO2.

Source: U.S. National Institute on Drug Abuse (NIDA), nida.nih.gov; PubChem, U.S. National Library of Medicine CID 1615.

Effects

Public health sources describe increased energy, distorted sensory and time perception, emotional warmth, and heightened sociability, alongside adverse effects such as nausea, muscle cramping, involuntary teeth clenching, chills, and sweating. In the days afterward some people experience low mood, irritability, and difficulty concentrating.

Source: U.S. National Institute on Drug Abuse (NIDA), nida.nih.gov

Onset & duration

NIDA describes MDMA's effects as lasting roughly 3 to 6 hours. Some people take a second dose as the first fades, which increases the risks.

Source: U.S. National Institute on Drug Abuse (NIDA), nida.nih.gov

Detection window

Detection windows depend on the test, the dose, and individual factors, so no single figure applies. General toxicology references discuss urine detection of amphetamine-type substances over a period of days; specifics should be confirmed against a laboratory source.

Source: MedlinePlus, U.S. National Library of Medicine

Risks & harms

A major risk is a dangerous rise in body temperature (hyperthermia), which can lead to failure of the heart, kidneys, or liver. Drinking excessive plain water to counter overheating can cause its own dangerous condition (hyponatremia) by diluting blood sodium — so volume is not protective. Combining MDMA with other stimulants, or with serotonergic drugs and MAOIs, raises the risk of serotonin toxicity.

Source: U.S. National Institute on Drug Abuse (NIDA), nida.nih.gov; MedlinePlus, U.S. National Library of Medicine.

Subjective effects

euphoria, emotional warmth, closeness/empathy, reduced inhibition, energy, heightened touch, sensual arousal, time/perception distortion

Short-term effects

confusion, anxiety, depression, paranoia, sleep problems, teeth clenching, nausea, sweating, chills, blurred vision, severe dehydration, craving

Long-term effects

possible long-term/permanent memory & learning problems; worse cognitive performance in chronic users; depression/anxiety days–weeks later

History

first synthesized by Merck 1912 (as "Methylsafrylamin"), as a precursor to a hemostatic drug; later used by some psychiatrists pre-prohibition

Images

Visual references coming soon.

If it’s too intense

If an experience becomes overwhelming, the goal is to stay safe and let it pass — most difficult experiences ease as the drug wears off.

  • Get to a calm, safe space with someone you trust who is sober and can stay with you.
  • Cool down if you’re overheating — move somewhere cool, remove extra layers, rest. Overheating is especially a risk with stimulants and MDMA.
  • Sip water to thirst — but don’t over-hydrate. Drinking large amounts of plain water (especially after MDMA) can dangerously dilute your blood sodium (hyponatremia). Electrolytes help more than volume.
  • Slow your breathing — long, slow exhales help settle a racing heart and anxiety.
  • A sugary drink, fruit juice, or a snack can ease shakiness and the anxiety that comes with low blood sugar.
  • Do not take more, and do not add another substance to manage it. Redosing or adding something else (including a sedative like a benzodiazepine) can make things worse, not better.

After MDMA, overheating and over-hydration are both dangerous: cool down, and sip to thirst rather than gulping water (forcing plain water can drop your blood sodium dangerously).

Call 911 (or Poison Control, 1-800-222-1222) right away for chest pain, a very high body temperature, a seizure, unconsciousness, or severe confusion. These are medical emergencies, not something to wait out.

Source: general harm-reduction guidance from SAMHSA, NIH/NIDA, and MedlinePlus, in our own words. Draft — not yet medically reviewed.

Forensic dossier

Draft · every field is source-cited or marked “Unknown — pending review”

Identity

IUPAC name
1-(1,3-benzodioxol-5-yl)-N-methylpropan-2-aminePubChem PUG-REST · retrieved 2026-06-18
SMILES
CC(CC1=CC2=C(C=C1)OCO2)NCPubChem PUG-REST · retrieved 2026-06-18
InChIKey
SHXWCVYOXRDMCX-UHFFFAOYSA-NPubChem PUG-REST · retrieved 2026-06-18
Synonyms / aliases
molly, ecstasy, Ecstasy, Midomafetamine, Methylenedioxymethamphetamine, midomafetamina, Methylenedioxymetamphetamine, Methylenedioxymethamfetamine, Mandy (Street Name), Molly (Street Name), XTC (Street Name), Ecstasy (Drug)PubChem PUG-REST + seed aliases · retrieved 2026-06-18

Composition

Composition
N/A — single compound (see Identity)

Physical / pill characteristics

Dosage form
Unknown — pending review (no Rx/OTC label; illicit — pill visuals = FIRST-PARTY submissions only, never generated or scraped)
Route
Unknown — pending review
Shape
Unknown — pending review
Color
Unknown — pending review
Imprint
Unknown — pending review
Score
Unknown — pending review

Scheduling & legal status

International
Unknown — pending review

Dosage

Pending medical reviewer

Sources

← Back to the drug index