LSA (Morning Glory)

LSA (lysergic acid amide, also called ergine) is a naturally occurring ergoline alkaloid and the main psychoactive constituent of certain seeds, notably morning glory and Hawaiian baby woodrose. It is chemically related to LSD and was studied by Albert Hofmann, but it produces a milder, more sedating and body-heavy experience. It has a long history of traditional use in Mesoamerican ritual.

Like LSD, LSA acts on serotonin receptors, including the 5-HT2A receptor central to psychedelic effects, though it binds less strongly than LSD, which is thought to explain its weaker psychedelic potency. It is an ergoline alkaloid, and ergot-related compounds also act on other receptors, contributing to side effects such as vasoconstriction and nausea.

Users describe a dreamy, sedating, introspective state with mild visual effects, quite different from the bright, energetic character of LSD. Nausea, vomiting, drowsiness, and heavy limbs are commonly reported, in part because the raw seeds contain other compounds and coatings. Effects are often described as unpredictable and physically uncomfortable.

LSA's most common problems are physical: pronounced nausea and vomiting, drowsiness, and — because it is an ergoline — vasoconstriction, the narrowing of blood vessels, which can be dangerous for people with cardiovascular conditions or when combined with other vasoconstricting drugs. Commercial morning glory seeds are frequently coated with fungicides or other chemical treatments intended to discourage ingestion, which can add their own toxicity. As a serotonergic drug, combining LSA with certain antidepressants (SSRIs, MAOIs) or other serotonergic substances raises the risk of serotonin syndrome, a potentially life-threatening reaction. Psychological distress is possible as with any psychedelic, especially in an unsafe setting. Seed potency varies widely between species and batches, so effects are hard to anticipate. Anyone with chest pain, signs of poor circulation, a severe psychiatric crisis, or high fever with rigidity needs urgent care — call 911, and Poison Control at 1-800-222-1222 can advise. This page has not yet been medically reviewed.